Type 2 Diabetes – What Happens To My Pancreas 101 ! ?

When faced with a diagnosis of Diabetes, education and knowledge is extremely important. The pancreas is usually a bit of a mystery for most people. This thing of so much interest sits in the abdomen and releases hormones. The most famous secretion is insulin. However, getting more knowledge of this gland can help patients with Type two Diabetes comprehend more fully their diagnosis. This pancreas is known an endocrine gland. Its main role is release of pancreatic fluid after a meal. Inside the pancreas, though, are some other small clusters of tissue that relate to insulin production. These go by the name of the islets of Langerhans.

 

The islets of Langerhans contain four different types of cells: beta, alpha, delta, and gamma. The beta cells are knowm to produce the insulin . Insulin performs many biological functions. It helps some cells then convert glucose into glycogen, which those cells use for energy. It helps convert certain amino acids into protein. It works in fat cells to take in glucose and aids in turning it into fat. It also helps reduce appetite in the hypothalamus gland. Insulin’s part in gluclose regulation and contris how it relates directly to diabetes. Diabetes Type 2 starts either when the islets of Langerhans stops synthesizing critically needed insulin or when the muscle cells begin to lose their ability to process insulin efficiently.

 

Type 2 diabetes develops when muscle cells begin to lose their ability to process insulin efficiently. Under the normal situation, muscle cells absorb glucose and use insulin to convert it into glycogen. In people with Diabetes 2, the muscle cells only convert a small portion of the glucose. For a short time, the islets of Langerhans in the pancreas will increase production of insulin. However, that is indeed not sustainable in the long term. Gradually, the amount of excess glucose begins to build in the blood stream. This situation goes by the tag of insulin resistance. The cells require more insulin to convert the same amount of glucose.

 

In those with type 2 diabetes, over time, in the pancreas, the beta cells in the islets of Langerhans that produce the insulin begin to decline over time. It is accepted that the quantity of insulin synthesised decreases. So, this then promotes the insulin requirement that alot of individuals in the later stages of the disease clearly show. To fight against this, medicine research trys to restore the levels of insulin synthesised. It is accepted that one area of research underway looks at the possibility of transplanting healthy islets of Langerhans into the pancreases of individuals with Type II Diabetes. There have been no successful transplants, but it is something that may happen in the future.

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This post was written by admin on August 24, 2010

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